Friday - June 28, 2019

New prospects in stroke prevention for atrial fibrillation patients in Vietnam

Ho Chi Minh City, June 22nd, 2019 – Bayer (South East Asia) Pte. Ltd. in Ho Chi Minh City (Bayer SEA) today brought together multi-disciplinary experts nationwide to discuss the latest advances in stroke prevention for atrial fibrillation (AF) patients. The symposium was hosted by Vietnam Cardiology Association.

PGS. TS. BS. Phạm Nguyễn Vinh, Phó Chủ tịch Hội Tim Mạch Học Việt Nam, Cố vấn Chuyên môn Bệnh viện Tim Tâm Đức, Chủ tọa hội thảo tại TP.HCM phát biểu khai mạc

Prof. Dr. Pham Nguyen Vinh, Chairman of Ho Chi Minh City Cardiology Association, Medical Director of Tam Duc Heart Hospital, Chairman of the symposium in Ho Chi Minh City gave the opening speech


The event was attended by more than 400 doctors nationwide who are cardiologists, neurologists, ICU and geriatrics nationwide, together with leading experts to exchange latest knowledge and share best practices on stroke management for Vietnamese patients. It also served as a platform for discussion on current challenges in achieving optimal AF stroke prevention in Vietnam.


Patients with atrial fibrillation (AF), a heart rhythm disorder, are at a five-fold higher risk of stroke than patients without AF. AF-related strokes are more likely to cause patients to remain in hospitals longer and face a higher risk of disability and death than strokes due to other causes. It is estimated that in 2050, Asia will have 72 million AF patients, and 2.9 million among them will suffer from an AF-associated stroke. According to statistics data [1], AF induced strokes generally results in severe consequences: 50% of AF induced strokes lead to death while the remaining 50% results in permanent disability.


NOACs: better efficacy, safety and convenience for patients


The use of the non-vitamin K antagonist oral anticoagulant (NOACs) for stroke prevention in AF patients has been recommended as a new standard and a preferred treatment in comparison with vitamin K antagonists (warfarin) at the European Society Congress (ESC) in 2016. The latest international guidelines recommend NOACs as first-line therapy for the management of AF-associated stroke, stating that NOACs offer better efficacy, safety and convenience compared with VKAs. NOACs are broadly preferable to VKAs in the vast majority of patients with AF[1].


“In comparison with warfarin, NOACs has proven advantages such as: fixed doses, lesser medicine and food interaction, no INR monitoring (via blood test) needed; hence offering better convenience for patients to adhere to treatment regimes,” said Prof. Dr. Pham Nguyen Vinh, Deputy President of the Vietnam Cardiology Association, Medical Director of Tam Duc Cardiology Hospital, the Chairman of the symposia.


“The new treatment offers a significantly lower risk of life-threatening bleedings especially intracranial (skull) bleeding in comparison with warfarin therapy; thus giving physicians reassurance to prescribe this NOACs instead of warfarin for patients with AF,” Vinh stressed.


Patients’ long-term and continual treatment for effective stroke management


According to the experts’ updates at the Healthy Heart Healthy Aging dialogue recently hosted by National University of Singapore, current available treatment options can reduce the risk of a first stroke from 50-70% in certain populations.


TS. BS. Nguyễn Huy Thắng, Chủ tịch Hội Đột quỵ TP. HCM chia sẻ những triển vọng mới trong xử trí và phòng ngừa đột quỵ

Prof. Nguyen Huy Thang, Chairman of Ho Chi Minh City Stroke Association shared new perspectives on stroke management and prevention


“However, the challenge is in adoption of treatment as most patients are reluctant to take medication and do not keep to their doctor visits schedule as recommended when they are feeling well. Therefore, it is important to educate the public and the wider community about the important role of NOAC in preventing AF-related stroke,” said Prof. Nguyen Huy Thang, Chairman of Ho Chi Minh City Stroke Association, Head of cerebrovascular pathology Department, Hospital People 115.


“In addition, certain NOACs can achieve safe and effective stroke prevention even in  high risk AF patients such as those who have had stroke before, patients with impaired kidney function, etc, It is important patients adhere strictly to their treatment regime, following examinations and recommendations regarding the use of anticoagulants as prescribed by their doctors and timely inform doctors about their disease conditions,” said Thang.


The good news is that Bayer’s NOACs have demonstrated real-world [3] stroke prevention outcomes and safety in NVAF patients across different risk profiles, with proven low major bleeding rates across Asian patients, high risk patients with co-morbidities [4] and patients with kidney impairment [5]

Các chuyên gia đầu ngành đang thảo luận và chia sẻ kiến thức chuyên môn tại Hội thảo khoa học về xử trí và dự phòng đột quỵ cho bệnh nhân rung nhĩ không do van tim

Panel discussion among experts in stroke prevention for non-valvular atrial fibrillation patients


“We believe that Bayer's NOACs will make a significant contribution to improving stroke prevention for AF patients in Vietnam. As a result, we are able to reduce the number of AF-related stroke incidents and the number of patients suffering from severe consequences of stroke such as permanent disability,” said Dr. Lynette Moey, Country Division of Pharmaceuticals in Vietnam, Managing Director of Bayer Vietnam.


“Being able to preserve the physical independence of patients and address the high unmet needs in AF stroke prevention are what motivates us to bring new and better medicine to  Vietnamese patients This is a testament to  our long-term commitment in developing high quality medicines for patients in Vietnam during our last 25 years of operation in the country.”


Reference source:

[1] (Wolf et al. 1991, Marini et al 2005, Kannel et al. 2008, Miyasaka et al 2006)

[2] Chiang CE1, Wang KL2, Lin SJ3. Asian strategy for stroke prevention in atrial fibrillation. Europace. 2015 Oct; 17 Suppl 2:ii31-ii39. (accessed on 27 June 2017)

[3] YH Kim, J Shim, CT Tsai, et al. XANAP: A Real­world, Prospective, Observational Study of Patients Treated with Rivaroxaban for Stroke Prevention in Atrial Fibrillation in Asia. Journal of Arrhythmia 2018; 01-10. (last accessed: 7 July 2018)

[4] MR Patel, KW Mahaffey, J Garg, et al. Rivaroxaban versus Warfarin in Non-valvular Atrial Fibrillation. N Engl J Med.2011 Sep 8;365(10) (last accessed: 11 May 2018); Giugliano RP, Ruff CT, Braunwald E, et al. Edoxaban versus Warfarin in Patients with Atrial Fibrillation. Engl J Med.2013 Nov 28; 369:2093-2104. (last accessed: 13 May 2018); [1]Granger CB, Alexander JH, Mcmurray JJV, et al.Apixaban versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med. 2011 Sep 15;365(11):981-92. (last accessed: 13 May 2018); Connolly SJ, Ezekowitz MD, S Yusuf, et al. Dabigatran versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med. 2009 Sep 17;361(12):1139-51. (last accessed: 13 May 2018)

[5] Fox KA, Piccini JP, Wojdyla D, et al. Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment. Eur Heart J .2011 Oct;32(19):2387-94. doi:10.1093/eurheartj/ehr342. (last accessed: 16 August 2018)


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